SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1580222
This article is part of the Research TopicThe crosstalk between emerging cell death and immune microenvironment remodeling in cancer progression and treatmentView all 12 articles
A Comprehensive Bibliometric Analysis of Ferroptosis in Tumor Resistance: Development and Emerging Trends
Provisionally accepted
- Henan University of Science and Technology, Luoyang, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Ferroptosis is a regulated form of cell death characterized by iron dependency, lipid peroxidation, and oxidative stress. Since its discovery in 2012, ferroptosis has attracted significant interest for its potential to counteract tumor resistance across various therapeutic modalities, including chemotherapy, radiotherapy, immunotherapy, and targeted therapy. Despite notable progress, a systematic understanding of its underlying molecular mechanisms and translational potential remains underdeveloped, thus necessitating a comprehensive bibliometric analysis.We employed bibliometric tools, including VOSviewer, CiteSpace, and bibliometric.com, to analyze 2,663 articles related to ferroptosis and tumor resistance indexed in the Web of Science Core Collection from 2014 to 2024. The analysis included co-occurrence, co-citation, and clustering techniques to explore trends, influential keywords, prominent journals, leading institutions, and key contributors. Citation burst detection and temporal analysis were used to uncover emerging research hotspots and track the field's evolution.Results: Over the past decade, the volume of publications in this field has grown rapidly, with China and the United States leading in both research output and academic influence. Notable institutions such as Central South University and Fudan University contributed significantly, while Kang Rui and Tang Daolin emerged as prolific authors. Key research hotspots identified include oxidative stress, tumor microenvironment, and nanomedicine, with emerging themes such as immunotherapy and autophagy gaining prominence. Temporal trends indicated a shift from mechanistic studies toward translational applications, emphasizing the integration of ferroptosis in clinical strategies to address tumor resistance.This bibliometric analysis highlights ferroptosis as a rapidly evolving field with significant contributions to understanding tumor resistance mechanisms. The identification of emerging themes and promising research directions offers valuable insights for future investigations and clinical applications of ferroptosis in overcoming tumor resistance.
Keywords: ferroptosis, bibliometric analysis, Tumor resistance, Oxidative Stress, Tumor Microenvironment
Received: 20 Feb 2025; Accepted: 21 Apr 2025.
Copyright: © 2025 Xie, Zhang, Niu, Yuan, Li and Yao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jun Yao, Henan University of Science and Technology, Luoyang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.