REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1577115
Janus Kinase Inhibitors for Alopecia Areata: A Review of Clinical Data
Provisionally accepted
- Third Hospital of Hebei Medical University, Shijiazhuang, China
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Alopecia areata (AA) is an autoimmune disease characterized by inflammatory and non-scarring hair loss, mediated by CD8+ T cells and primarily affecting hair follicles. Janus Kinase (JAK) inhibitors selectively inhibit JAK, block the signal transducer and activator of transcription pathway, and often interfere with T cell-mediated inflammatory cytokine pathways. They are a class of targeted antiinflammatory drugs that can promote the activation of hair follicle stem cells. Studies have shown that JAK inhibitors exhibited good efficacy and safety in the treatment of AA, with fewer serious side effects. This article reviews the mechanism of action of JAK inhibitors in the treatment of AA, as well as the effects and side effects of representative drugs.
Keywords: Alopecia Areata, Janus Kinases, Baricitinib, Ritlecitinib, Deuruxolitinib
Received: 17 Feb 2025; Accepted: 10 Apr 2025.
Copyright: © 2025 Sun, Zhang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yanli Zhang, Third Hospital of Hebei Medical University, Shijiazhuang, China
Yaling Liu, Third Hospital of Hebei Medical University, Shijiazhuang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.