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CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1576053
This article is part of the Research Topic Autoimmune Diseases: from molecular mechanisms to therapy development View all 7 articles
A CASE OF PEDIATRIC PERSISTENT REFRACTORY ITP RESPONSIVE TO
Provisionally accepted- 1 Santo Spirito Hospital, Pescara, Italy
- 2 Department of Medicine and Sciences of Aging, G. d'Annunzio University of Chieti and Pescara, Chieti, Italy
Immune thrombocytopenia (ITP) is a rare hematologic disorder characterized by low platelet counts due to an immune-mediated destruction of platelets. While corticosteroids, intravenous immunoglobulin (IVIG) are the mainstays of treatment, a subset of patients may remain refractory to these therapies. Here, we present a case of a 6-year-old girl diagnosed with refractory ITP, who failed to respond to standard therapies but showed a remarkable clinical improvement with avatrombopag, a thrombopoietin receptor agonist.
Keywords: immune thrombocytopaenia (ITP), Avatrombopag, Thrombopoietin receptor (TPOr) agonists, Children, Platelet, PERSISTENT OR CHRONIC IMMUNE THROMBOCYTOPENIA
Received: 13 Feb 2025; Accepted: 31 Mar 2025.
Copyright: © 2025 Sau, Di Prinzio, Onofrillo, Russo and Di Ianni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Antonella Sau, Santo Spirito Hospital, Pescara, Italy
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