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REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1575516
This article is part of the Research Topic Precision Medicine in Immunology: Targeting Inflammation to Improve Patient Care with Immune Diseases View all articles
Targeting the Immuno-Inflammatory-Microbial Network: A Key Strategy for Sepsis Treatment
Provisionally accepted- Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
Abstract：Sepsis is a life-threatening condition caused by a dysregulated host response to infection, remaining a major global health challenge despite clinical advances. Therapeutic challenges arise from antibiotic misuse, incomplete understanding of its complex pathophysiology, and the unresolved interplay of immune dysregulation and microbiota disruption. Investigating microbial homeostasis in the shift from cytokine storm to immunosuppression may elucidate the interplay between microbial metabolites, immune dysfunction, and organ injury, providing a foundation for targeted therapies and drug development. Traditional Chinese Medicine (TCM) has demonstrated significant advantages in mitigating sepsis-associated cytokine storms and modulating gut microbiota homeostasis, offering a promising strategy for developing highly effective and less toxic targeted monomeric compounds. Elucidating the interactions within the immune-inflammationmicrobiota network in sepsis paves the way for biomarker-driven personalized therapeutic approaches.
Keywords: Cytokine storm, Immune balance, Probiotics, treatment outcome, Traditional Chinese medicine (TCM)
Received: 12 Feb 2025; Accepted: 27 Mar 2025.
Copyright: © 2025 Xu, Wang, Yuan, Qin, Long and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yue Xu, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
Peiyang Gao, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.