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GENERAL COMMENTARY article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1575090
This article is part of the Research Topic The Tumor Microenvironment and Immunotherapy for Head and Neck Tumors View all 16 articles
Commentary: Disulfidptosis-related gene signatures as prognostic biomarkers and predictors of immunotherapy response in HNSCC
Provisionally accepted- 1 Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China
- 2 The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
- 3 Department of Center for Renal Diseases, Sichuan Provincial People's Hospital East Sichuan Hospital & Dazhou First People's Hospital, Dazhou, China
Analysis"-they believed that in high-risk HNSCC, the sensitivity of belinostat, SB52334, and CAL-29 101 was significantly higher than in the low-risk group, while Dasatinib, Pazopanib, and Docetaxel 30 showed higher sensitivity in low-risk HNSCC (1). 31 IC50, defined as the half maximal inhibitory concentration, signifies the concentration at which a 32 drug or inhibitor diminishes the activity of a biological process (such as an enzyme, receptor, or cell) 33 to half of its maximum level under specific experimental conditions. A lower IC50 value indicates 34 that the drug can achieve a 50% inhibitory effect at a lower concentration, suggesting a higher potency and sensitivity of the drug (2,3). Therefore, the correct interpretation of Figure 11B
Keywords: Half maximal inhibitory concentration (IC50), medication, disulfidptosis-related genes (DRGs), Head and neck squamous cell carcinoma (HNSCC), Immunotherapy
Received: 11 Feb 2025; Accepted: 04 Mar 2025.
Copyright: © 2025 Xue, Xue, Yin, Chen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ming Wang, Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China
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