LncRNA29RIK in macrophages promotes LPS mediated sensitivity to obesity

Wang, Rong; Yunhuan, Gao; Wang, Ya; Yuan, Zhang; Yang, Rongcun

doi:10.3389/fimmu.2025.1574507

ORIGINAL RESEARCH article

Front. Immunol.

Sec. Inflammation

Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1574507

LncRNA29RIK in macrophages promotes LPS mediated sensitivity to obesity

Provisionally accepted

Rong Wang

Gao Yunhuan Ya Wang

Ya Wang

Zhang Yuan

Rongcun Yang ^*

Nankai University, Tianjin, China

The final, formatted version of the article will be published soon.

Lipopolysaccharide (LPS, endotoxin) -mediated signaling of caspase-4 (human) and -11 (rodent) can induce the maturation of inflammatory cytokine IL-1β and cell pyroptosis, which is associated with the pathophysiology of many diseases such as obesity. However, the process by which LPS induces inflammation through caspase 4/11 is not fully understood. We found here that lncRNA29RIK plays a key role in LPS-mediated maturation of inflammatory cytokine IL-1β and pyroptosis of macrophages. Mechanistic ally, the binding of caspase 4/11 to LPS requires lncRNARIK to cause activation of the caspase 4/11 complex, which ultimately caused inflammation to promote sensitivity to high fat diet (HFD) -mediated obesity.Notably, lncRNA29RIK expression can be up-regulated by LPS. This lncRNA29 is highly conserved between humans and mice. Taken together, these results suggest that lncRNA29RIK determines the occurrence and progression of LPS-related diseases such as obesity.

Keywords: Obesity, Macrophages, lncRNARIK, Caspase 4, pyroptosis

Received: 10 Feb 2025; Accepted: 25 Mar 2025.

Copyright: © 2025 Wang, Yunhuan, Wang, Yuan and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Rongcun Yang, Nankai University, Tianjin, China

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