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REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1573905
This article is part of the Research Topic The Pivotal Role of Cytokines in Autoimmune Diseases View all 11 articles
Interventions in Cytokine Signaling: Novel Horizons for Psoriasis Treatment
Provisionally accepted
Lisha Li 1,2,3
Jun Liu 1,2 Jiaye Lu 1,2
Junchao Wu 1,2
XinYue Zhang 1,2 Tianyou Ma 1,2 Xiying Wu 1,2 Quangang Zhu 1,2*
Zhongjian Chen 1,2*
Zongguang Tai 1,2*- 1 Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China
- 2 Shanghai Engineering Research Center of Topical Chinese Medicine,, shanghai, China
- 3 Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
Intricate interactions between immune cells and cytokines define psoriasis, a chronic inflammatory skin condition that is immunological-mediated. Cytokines, including interleukins (ILs), interferons (IFNs), tumor necrosis factors (TNFs), chemokines, and transforming growth factor-β (TGF-β), are essential for controlling cellular activity and immunological responses, maintaining homeostasis and contributing to the pathogenesis of psoriasis. These molecules modulate the immune microenvironment by either promoting or suppressing inflammation, which significantly impacts therapeutic outcomes. Recent research indicates that treatment strategies targeting cytokines and chemokines have significant potential, offering new approaches for regulating the immune system, inhibiting the progression of psoriasis, and reducing adverse effects of traditional therapies. This review consolidates current knowledge on cytokine and chemokine signaling pathways in psoriasis and examines their significance in treatment. Specific attention is given to cytokines like IL-17, IL-23, and TNF-α, underscoring the necessity for innovative therapies to modulate these pathways and address inflammatory processes. This review emphasizes the principal part of cytokines in the -pathological process of psoriasis and explores the challenges and opportunities they present for therapeutic intervention. Furthermore, we examine recent advancements in targeted therapies, with a particular focus on monoclonal antibodies, in ongoing research and clinical trials.
Keywords: Psoriasis, Inflammatory skin disease, immune cells, Cytokines, cytokine network Caspase Recruitment Domain 14 CSFs: Colony-Stimulating Factors CXCL: Chemokine (C-X-C motif) Ligand DC: Dendritic cell GDF11: Growth Differentiation Factor 11 Peripheral Blood Mononuclear Cells
Received: 10 Feb 2025; Accepted: 27 Mar 2025.
Copyright: © 2025 Li, Liu, Lu, Wu, Zhang, Ma, Wu, Zhu, Chen and Tai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Quangang Zhu, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China
Zhongjian Chen, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China
Zongguang Tai, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.