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MINI REVIEW article
Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1572140
This article is part of the Research Topic Central nervous system autoimmunity and autoinflammation: insights from inborn errors of immunity View all 4 articles
The role of NLRP3 inflammasome in multiple sclerosis: pathogenesis and pharmacological application
Provisionally accepted- General Hospital of Chinese PLA, Beijing, China
Multiple sclerosis (MS) is widely acknowledged as a chronic inflammatory autoimmune disorder characterized by central nervous system (CNS) demyelination and neurodegeneration. The hyperactivation of immune and inflammatory responses is recognized as a pivotal factor contributing to the pathogenesis and progression of MS.Among various immune and inflammatory reactions, researchers have increasingly focused on the inflammasome, a complex of proteins. The initiation and activation of the inflammasome are intricately involved in the onset of MS. Notably, the NLRP3 inflammasome, the most extensively studied member of the inflammasome complex, is closely linked with MS. This review will delve into the roles of the NLRP3 inflammasome in the pathogenesis and progression of MS. Additionally, therapeutic strategies targeting the NLRP3 inflammasome for the treatment of MS, including natural compounds, autophagy regulators, and other small molecular compounds, will be detailed in this review.
Keywords: Multiple Sclerosis, NLRP3 inflammasome, Inflammation, Experimental autoimmune encephalomyelitis, Autophagy
Received: 20 Feb 2025; Accepted: 21 Mar 2025.
Copyright: © 2025 Zhang, Zheng, Yao, Sun and Shao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bo-Zong Shao, General Hospital of Chinese PLA, Beijing, China
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