95% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1572108
This article is part of the Research Topic PANoptosis and its role in T cell-based immunotherapy View all 4 articles
Comprehensive Pan-Cancer Analysis Identifies PLAG1 as a Key Regulator of Tumor Immune Microenvironment and Prognostic Biomarker
Provisionally accepted- 1 Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London, England, United Kingdom
- 2 West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
- 3 Ningbo Diagnostic Pathology Center, Ningbo, Zhejiang Province, China
Background: The literature on the role of pleomorphic adenoma gene 1 (PLAG1) in malignant tumors is limited. This study aimed to perform pan-cancer analysis of PLAG1. Methods: The expression of PLAG1 was analyzed by Human Protein Atlas (HPA). The differential expression and prognosis of PLAG1 were analyzed based on TCGA pan-cancer data. The relationship between PLAG1 expression and tumor heterogeneity, stemness and immune infiltration was investigated. The enrichment analysis and biological function of PLAG1 in bladder cancer were analyzed. Results: The expression of PLAG1 was increased in a variety of tumors and significantly correlated with the prognosis of patients. Their expression levels were associated with key immune checkpoint genes (CD274, HAVCR2), immune infiltration and immune stimulation factors (CD48, CD27). In bladder cancer, functional enrichment analysis indicated that PLAG1 was involved in epidermal related processes and immune pathways. PLAG1 gene knockout can significantly inhibit the proliferation of bladder cancer cells.Conclusions: PLAG1 has the potential to be a prognostic marker and a potential therapeutic target for patients with malignant tumors.
Keywords: Pan-cancer analysis, Pleomorphic adenoma gene 1, biomarker, Tumorinfiltrating cells, Tumor Microenvironment
Received: 06 Feb 2025; Accepted: 25 Mar 2025.
Copyright: © 2025 Wu, Li, Zhang, Wang, Yu, Feng and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dechao Feng, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.