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REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1570698
This article is part of the Research Topic Oncolytic Viruses in Cancer Treatment: Exploring Molecular Mechanisms View all 3 articles
Oncolytic Viruses: A Promising Therapy for Malignant Pleural Effusion and Solid Tumors
Provisionally accepted- Hubei University of Technology, Wuhan, China
Oncolytic viruses (OVs) are natural or recombinant viruses that can directly lyse tumor cells without damaging normal cells. They enhance anti-tumor immunity by releasing antigens and activating inflammatory responses within the tumor microenvironment (TME). This offers a new therapeutic approach for MPE and solid tumors. This review discusses the progress of OVs administered via intrapleural and intratumoral routes, emphasizing their potential in MPE treatment and the challenges posed by the complex intrapleural environment, which affects the direct interaction between OVs, tumor cells, and immune cells. This review also discusses the regulatory barriers, safety concerns and accessibility of Oncolytic virus therapy.
Keywords: oncolytic virus, malignant pleural effusion, Tumor Microenvironment, Solid tumor, Intracavitary administration
Received: 04 Feb 2025; Accepted: 31 Mar 2025.
Copyright: © 2025 Wang, Zhou, Zhang, Hu, Liu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yang Wang, Hubei University of Technology, Wuhan, China
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