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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Immunological Tolerance and Regulation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1569283
A dominant, pan-DR binding epitope of Der p 1 in house dust mite allergy induces tolerance in HLA-DR4 transgenic mice
Provisionally accepted
Heather B Streeter 1*
Lora G Lucas 1
Robert West 2
Mamidipudi Thirumala Krishna 1,3
David Cameron Wraith 1*- 1 Birmingham Medical School, University of Birmingham, Birmingham, England, United Kingdom
- 2 Leeds Institute of Health Sciences, Faculty of Medicine and Health, University of Leeds, Leeds, England, United Kingdom
- 3 University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
HBS, LGL, RMW, MTK, DCW. The study was conceived and designed by HBS, MTK and DCW. Data was acquired by HBS, LGL and MTK. All authors analysed and interpreted data. All authors wrote and reviewed the manuscript. We thank Joseph Clarke for technical assistance and research nurses Tabinda Kharodia, Faye Moore and Shamin Onyango-Odera for assistance with screening, recruitment of participants and collection of clinical samples. We are also grateful to individuals who participated in this study and Allergy UK for supporting this study from a patient and public involvement and engagement perspective.
Keywords: allergy, DerP1, epitope, Immunotherapy, tolerance
Received: 31 Jan 2025; Accepted: 21 Mar 2025.
Copyright: © 2025 Streeter, Lucas, West, Krishna and Wraith. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Heather B Streeter, Birmingham Medical School, University of Birmingham, Birmingham, B15 2TT, England, United Kingdom
David Cameron Wraith, Birmingham Medical School, University of Birmingham, Birmingham, B15 2TT, England, United Kingdom
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