95% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1569150
This article is part of the Research Topic Exploring the role of immune cells and cell therapy in liver cancer View all 9 articles
Exploration of the Role of Immune Cells and Cell Therapy in Hepatocellular Carcinoma
Provisionally accepted- 1 Faculty of Hepato-Pancreato-Biliary Surgery, First Medial Center of Chinese PLA General Hospital, Beijing, China
- 2 The Second Clinical College, Chongqing Medical University, chongqing, China
- 3 medical center of PLA general hospital, Beijing, China
Hepatocellular carcinoma stands as one of the foremost contributors to cancer-associated fatalities globally, and the limitations of traditional treatment methods have prompted researchers to explore new therapeutic options. Recently, cell therapy has emerged as a promising approach for HCC, showing significant potential in improving patient outcomes. This review article explores the use of cell therapy for HCC, covering different types, the mechanisms behind their effectiveness, recent advancements in clinical trials, and ongoing challenges. This article aims to provide insightful perspectives for future research and clinical applications in treating HCC by synthesizing current knowledge.
Keywords: Hepatocellular Carcinoma, cell therapy, immune cells, Immunotherapy, Tumor Microenvironment
Received: 31 Jan 2025; Accepted: 27 Mar 2025.
Copyright: © 2025 Zhang, Ren, Yang, Zhang and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ning Zhang, Faculty of Hepato-Pancreato-Biliary Surgery, First Medial Center of Chinese PLA General Hospital, Beijing, China
Haowen Tang, medical center of PLA general hospital, Beijing, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.