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MINI REVIEW article
Front. Immunol.
Sec. Mucosal Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1568541
This article is part of the Research Topic Immune Responses at Barrier Tissues: Insights from Synthetic Biology in Therapeutics, Diagnostics, Mechanisms, and Beyond View all 6 articles
Inflammatory and Homeostatic Roles of Eosinophil Subpopulations in Chronic Rhinosinusitis with Nasal Polyp Pathogenesis
Provisionally accepted
Kantapat Simmalee 1*
Putthapoom Lumjiaktase 1*
Theerasuk Kawamatawong 2
Amir Guemari 3
Valérian Dormoy 4
Joana Vitte 3,4- 1 Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
- 2 Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
- 3 Faculté de Médecine, Université Reims Champagne-Ardenne, Reims, Champagne-Ardenne, France
- 4 INSERM UMRS1250 Pathologies Pulmonaires et Plasticité Cellulaire (P3Cell), Reims, Champagne-Ardenne, France
Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) mainly expresses type-2 endotype, featuring eosinophils as a main player in the inflammatory process. Prolonged eosinophilia in the tissues of asthma and CRSwNP patients has been associated with structural changes, leading to fixed airflow obstruction in asthma and nasal polyposis in CRSwNP. This suggests that eosinophils may belong to different subgroups playing distinct roles in pathogenesis. Recent studies highlight the roles of inflammatory eosinophils (iEOS) in driving inflammation and tissue damage, whereas tissue-resident eosinophils (rEOS) maintain homeostasis and tissue repair in the airway. Therefore, understanding both roles of eosinophil subpopulations is crucial for better CRSwNP management, including enhancing the diagnosis accuracy, predicting recurrence, and optimizing treatment strategies.
Keywords: chronic rhinosinusitis with nasal polyps, eosinophil, Eosinophil Subpopulations, Inflammatory eosinophils, Resident eosinophils
Received: 30 Jan 2025; Accepted: 24 Mar 2025.
Copyright: © 2025 Simmalee, Lumjiaktase, Kawamatawong, Guemari, Dormoy and Vitte. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kantapat Simmalee, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand
Putthapoom Lumjiaktase, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand
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