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REVIEW article
Front. Immunol.
Sec. NK and Innate Lymphoid Cell Biology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1567817
The role of ILC2s in asthma combined with atopic dermatitis: bridging the gap from research to clinical practice
Provisionally accepted- Southwest Medical University, Luzhou, China
Asthma, a complex and heterogeneous respiratory disease, is often accompanied by various comorbidities, notably atopic dermatitis (AD). AD characterized by recurrent eczematous lesions and severe itching, can trigger or exacerbate asthma. Individuals with AD are 2.16 times more likely to develop asthma compared to the reference population. Furthermore, asthmatics with AD experience more severe and frequent emergency department visits and hospital admissions compared to patients with asthma alone. The close connection between asthma and AD indicates there are overlap pathophysiologic mechanisms. It is well-known that dysregulated type 2 (T2) immune inflammation is pivotal in the development of both AD and asthma, traditionally attributed to CD4 + type 2 helper T (Th2) cells. Over the past decade, group 2 innate lymphoid cells (ILC2s), as potent innate immune cells, have been demonstrated to be the key drivers of T2 inflammation, playing a crucial role in the pathogenesis of both asthma and AD. ILC2s not only trigger T2
Keywords: Group 2 innate lymphoid cells, Asthma, atopic dermatitis, asthma combined with atopic dermatitis, biologics
Received: 28 Jan 2025; Accepted: 11 Mar 2025.
Copyright: © 2025 Luo, Deng, Yang, Siji, Xiong, Yuan and Ao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yulai Yuan, Southwest Medical University, Luzhou, China
Suhua Ao, Southwest Medical University, Luzhou, China
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