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REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1567293
This article is part of the Research TopicCommunity Series: Systemic Vasculitis: Advances in Pathogenesis and Therapies Volume IIView all 3 articles
Anti-endothelial cell antibodies (AECAs) in pathogenesis of vasculitis
Provisionally accepted- 1Laboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China
- 2Shandong Provincial Key Medical and Health Laboratory of Translational Medicine in Microvascular Aging, Jinan, China
- 3Laboraotry for Future Industry in Gene Editing in Vascular Endothelial Cells of Universities of Shandong Province, Jinan, China
- 4Department of Clinical Laboratory, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, China
- 5Gomel State Medical University, Gomel, Gomel Region, Belarus
- 6Institute of Radiobiology of NAS of Belarus, Gomel, Belarus, Gomel, Belarus
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Vasculitis is a group of syndromes characterized by inflammation, presence of autoantibodies and endothelial cells (ECs) damage, which lead to stenosis or occlusion of the vascular lumen. Antiendothelial cell antibodies (AECAs) are a heterogeneous group of autoantibodies in vasculitis. AECAs bind to antigens and membrane-bound proteins of ECs, inducing inflammation, coagulation, and apoptosis. In this review, we discuss the pathological role of AECAs in different types of vasculitis. In addition, AECAs potentially induce alterations of ECs mechanical properties, and subsequently promotes angiogenic phenotypes in the occurrence of vasculitis.
Keywords: Vasculitis, Endothelial Cells, Anti-endothelial cell antibodies (AECAs), Angiogenesis, Mechanical Properties, stiffness
Received: 27 Jan 2025; Accepted: 09 Apr 2025.
Copyright: © 2025 Zhang, Li, Huang, Starodubtseva and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ju Liu, Laboratory of Translational Medicine in Microvascular Regulation, Medical Research Center, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.