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CASE REPORT article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1567277
Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposition Coexisting with ANCA-Associated Glomerulonephritis: A Case Report
Provisionally accepted- Wenzhou Central Hospital, Wenzhou, China
Proliferative glomerulonephritis with monoclonal immunoglobulin deposition (PGNMID) is a rare variant of monoclonal gammopathy of renal significance (MGRS). Although the pathogenesis of PGNMID is not yet fully understood, it is currently hypothesized to originate from the intraglomerular deposition of pathogenic monoclonal immunoglobulins secreted by B cells or plasma cells. Typically, these deposits exhibit light chain restriction, with κ light chains being the most prevalent. Therapeutic strategies for PGNMID are based on targeting the abnormal or potential clone. However, the combination of corticosteroids and cyclophosphamide has also been reported. In this report, we describe an extremely rare clinical case of λ light chain type PGNMID occurring simultaneously with ANCA-associated glomerulonephritis. After treatment with the combination of corticosteroids and cyclophosphamide, the patient demonstrated reduced proteinuria and stable renal function.
Keywords: proliferative glomerulonephritis with monoclonal immunoglobulin deposition, monoclonal gammopathy of renal significance, ANCA-associated glomerulonephritis, corticosteroids, Cyclophosphamide
Received: 27 Jan 2025; Accepted: 31 Mar 2025.
Copyright: © 2025 Cheng, Zhang, Chen, Zheng and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zemin Wang, Wenzhou Central Hospital, Wenzhou, China
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