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MINI REVIEW article
Front. Immunol.
Sec. Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1566985
This article is part of the Research Topic Autoinflammatory novelties: from pathogenic mechanisms to clinical and therapeutic implications View all 4 articles
Pyroptosis in Kawasaki Disease: from Mechanisms to Targeted Intervention
Provisionally accepted
Xiangyu Han 1*
Hui-Ru Qi 2,3- 1 First Hospital, Peking University, Beijing, China
- 2 Peking University, Beijing, Beijing Municipality, China
- 3 Capital Institute of Pediatrics, Beijing, Beijing Municipality, China
Kawasaki disease (KD) is a relatively common autoimmune disease of childhood, characterized by systemic vasculitis and involvement of cardiovascular system, particularly the coronary artery. The progressive inflammatory cascades and vascular injury are regarded as two major processes underlying KD. Although it's regarded as a self-limiting disease, some children exhibit resistance to intravenous immunoglobulin (IVIG) treatment, which can lead to the development of life-threatening coronary artery aneurysms that persist into adulthood. Pyroptosis, a special inflammatory cell death pattern, results in the intense release of inflammatory mediators and injuries of tissues like endothelial cell damage. Evidence from in vitro studies and animal models suggest that pyroptosis and associated inflammatory cascades may play a significant role in KD. Here, we highlight the latest insights into pyroptosis in KD and explore the potential therapeutic translation by targeting pyroptosis.
Keywords: kawasaki disease, pyroptosis, Inflammation, intervention Kawasaki disease, intervention
Received: 26 Jan 2025; Accepted: 26 Mar 2025.
Copyright: © 2025 Han and Qi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiangyu Han, First Hospital, Peking University, Beijing, China
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