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EDITORIAL article
Front. Immunol.
Sec. T Cell Biology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1566491
This article is part of the Research Topic Current Insights in Cancer Metabolism and T Cell Based Tumor Immunity View all 5 articles
Editorial: Current Insights in Cancer Metabolism and T cell-based Tumor Immunity
Provisionally accepted- 1 National Institutes of Health (NIH), Bethesda, United States
- 2 Josai University, Sakado, Japan
- 3 Nanjing University, Nanjing, Jiangsu Province, China
Shen et al. identified differences in immune activity, lipid biosynthesis, and drug metabolism between low-and high-risk survival groups of estrogen receptor-positive breast cancer patients (ER+BR) (5). The analysis revealed that high-risk patients express high levels of ALOX15, a gene associated with lipid metabolism, which is positively correlated with tumor size and vascular invasion. The authors have suggested that modulation of lipid metabolism could enhance the efficacy of anticancer therapies.In conclusion, metabolism within the tumor microenvironment plays a crucial role in regulating both the tumor growth and the immune response. Lipid metabolism exerts a significant influence on the characteristics of tumor microenvironment and the functionality of immune cells. A comprehensive understanding of these metabolic interactions could facilitate the development of innovative therapeutic strategies that combine metabolic modulation with immune checkpoint inhibitors to enhance anti-tumor immunity.
Keywords: cancer metabo;osm, cancer immunology, immune chechpoint inhibitor, Tumor biology, Glycolysis
Received: 24 Jan 2025; Accepted: 10 Feb 2025.
Copyright: © 2025 MaruYama, Tanikawa and Gu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Takashi MaruYama, National Institutes of Health (NIH), Bethesda, United States
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