CASE REPORT article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1565388
This article is part of the Research TopicAdvances in Ocular Autoimmune DiseasesView all 3 articles
IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance
Provisionally accepted
- 1West China Hospital, Sichuan University, Chengdu, China
- 2363 Hospital, Chengdu, Chengdu, Sichuan Province, China
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IgG4-related disease (IgG4-RD), an immune-mediated fibroinflammatory disorder, has few reports in combination with monoclonal gammopathy of undetermined significance (MGUS).Herein, we present a case of a 69-year-old woman with manifestations of left orbital occupation and visual acuity decline. Ancillary tests indicated persistent positivity of IgG4 antibody, and IgG4-RD-related ophthalmopathy was diagnosed based on the criteria. Concurrently, serum protein electrophoresis revealed an M protein level of 12.23 g/L. Immunofixation electrophoresis suggested a positive IgG λ-type M protein, and MGUS was diagnosed in conjunction with bone marrow smear and flow cytometry.
Keywords: IgG4-RD-related ophthalmopathy, diagnostic criteria, M protein, IgE, monoclonal gammaglobulinemia of undetermined significance
Received: 23 Jan 2025; Accepted: 21 Apr 2025.
Copyright: © 2025 Liang, Xu, Zhong, Tao, Zhang and Jia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Li Zhang, West China Hospital, Sichuan University, Chengdu, China
Chengyao Jia, West China Hospital, Sichuan University, Chengdu, China
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