SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Alloimmunity and Transplantation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1564551
Comparisons of Liver Transplant from DCD outcomes in High-utilization centers versus Low-utilization centers in the US: A Systematic Review and Meta-Analysis
Provisionally accepted
Joao Lucas Lima Manzi1
Eduarda Saba-Oliveira1
Sarah Rombach1
Vitor Bicarato Turra1
Simone Zaragoza1Yanik Bababekov2Trevor Nydam2
Alfred Joseph Tector1
Rodrigo Vianna1
Phillipe Abreu2*- 1University of Miami, Coral Gables, United States
- 2University of Colorado Anschutz Medical Campus, Aurora, United States
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What are the differences in outcomes between high and low-utilization centers in liver transplants from donors after cardiac death (DCDs)?Findings: In this meta-analysis of 898 liver transplant patients from DCDs, the high utilization centers showed a 1-year graft survival of 90.9% (95% CI: 88.4 -92.9; I2 = 0%), and low utilization centers showed 89.4% (95% CI: 83.8 -93.2; I2 = 0%), with a pvalue between groups of 0.54. For 1-year patient survival, high utilization centers had a rate of 94.6% (95% CI: 92.4 -96.1; I2 = 0%), and low utilization centers had 93.7% ( 95% CI: 79. -99.23; I2 = 0%), with a p-value between groups of 0.84.Meaning: Although low-utilization centers have a higher selectivity for DCD organs, there is no statistically relevant difference compared to high-utilization centers, which may be caused by a compensatory higher experience in the latter.
Keywords: liver transplant, Donor after cardiac death, Liver Transplantation, organ donation, Rapid recovery DCD, Center volume
Received: 21 Jan 2025; Accepted: 11 Apr 2025.
Copyright: © 2025 Lima Manzi, Saba-Oliveira, Rombach, Bicarato Turra, Zaragoza, Bababekov, Nydam, Tector, Vianna and Abreu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Phillipe Abreu, University of Colorado Anschutz Medical Campus, Aurora, United States
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