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REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1563725
This article is part of the Research Topic Advancing Cancer Therapy: Innovative Strategies Targeting Immune Evasion and Metabolic Modulation View all 5 articles
Pancreatic Cancer Subtyping -The Keystone of Precision Treatment
Provisionally accepted- 1 Lanzhou University, Lanzhou, China
- 2 Lanzhou University Second Hospital, Lanzhou, Gansu Province, China
In recent years, the incidence and mortality rates of pancreatic cancer have been rising, posing a severe threat to human health. Tumor heterogeneity remains a critical barrier to advancing diagnosis and treatment efforts. The lack of specific early symptoms, limited early diagnostic methods, high biological complexity, and restricted therapeutic options contribute to the poor outcomes and prognosis of pancreatic cancer. Therefore, there is an urgent need to explore the different subtypes indepth and develop personalized therapeutic strategies tailored to each subtype. Increasing evidence highlights the pivotal role of molecular subtyping in treating pancreatic cancer. This review focuses on recent advancements in classifying molecular subtypes and therapeutic approaches, discussed from the perspectives of gene mutations, genomics, transcriptomics, proteomics, metabolomics, and immunomics.
Keywords: Pancreatic Cancer, subtypes, Genomics, Transcriptomics, Proteomics, Metabolomics, immunomics
Received: 20 Jan 2025; Accepted: 17 Mar 2025.
Copyright: © 2025 Fan, Xiao, Du, Zhang and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wence Zhou, Lanzhou University, Lanzhou, China
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