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REVIEW article
Front. Immunol.
Sec. Nutritional Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1563504
This article is part of the Research Topic Impact of Dietary Nanoparticles on Food Allergy Development and Immune Response View all articles
Inorganic Dietary Nanoparticles in Intestinal Barrier Function of Inflammatory Bowel Disease: Allies or Adversaries?
Provisionally accepted- 1 Guangzhou First People's Hospital, Guangzhou, Guangdong Province, China
- 2 The First People's Hospital of Foshan, Foshan, China
Inorganic dietary nanoparticles (IDNPs) are frequently utilized as food additives and in packaging, resulting in their exposure becoming a substantial yet often overlooked concern for patients with inflammatory bowel disease (IBD). Considering that impaired intestinal barrier function plays a central role in the pathogenesis of IBD, this review concentrates on the roles and mechanisms of IDNPs in the intestinal barrier (physical, chemical, biological, and immune barriers) of IBD patients.Previous studies have shown that different types of nanoparticles have varying effects on animals in diverse states. In this context, factors such as the source, size, shape, dosage, and duration of action of the nanoparticles, as well as the species, gender, dietary habits, and age of the animals, significantly influence research outcomes. Future studies should undertake more comprehensive explorations into the effects and mechanisms of IDNPs with diverse sources and properties in IBD patients.
Keywords: Inorganic dietary nanoparticles, inflammatory bowel disease, intestinal barrier, Immune barrier, Biological barrier
Received: 20 Jan 2025; Accepted: 24 Mar 2025.
Copyright: © 2025 Luo, Luo, Xu, Li, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Kangbao Li, Guangzhou First People's Hospital, Guangzhou, 510180, Guangdong Province, China
Zhaotao Li, The First People's Hospital of Foshan, Foshan, China
Cong Zhang, The First People's Hospital of Foshan, Foshan, China
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