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REVIEW article
Front. Immunol.
Sec. Systems Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1561061
Anti-Ro/SSA Antibodies in Adult Arrhythmias: Pathogenesis, Clinical Implications, and Therapeutic Strategies
Provisionally accepted- Department of Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
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Anti-Ro/SSA antibodies, prevalent autoantibodies in connective tissue diseases, have well-established roles in fetal arrhythmias but their significance in adult arrhythmias remains underrecognized. Recent evidence highlights that anti-Ro/SSA antibodies may induce adult arrhythmias by disrupting cardiac ion channel function, particularly through interactions with calcium and potassium channels, leading to electrophysiological disturbances including QT prolongation, atrioventricular block, and increased susceptibility to sudden cardiac death.Additionally, these antibodies can initiate inflammatory cascades, further contributing to myocardial fibrosis and conduction abnormalities. Despite the growing clinical relevance, detection of anti-Ro/SSA antibodies in unexplained arrhythmias is not routinely performed, limiting early recognition and intervention. Therapeutic strategies, currently based primarily on immunomodulatory therapies, show promise yet lack definitive evidence from randomized controlled trials. This review systematically summarizes recent advances regarding the pathogenic mechanisms, clinical implications, and therapeutic strategies for anti-Ro/SSA antibody-associated adult arrhythmias, aiming to enhance awareness, diagnostic precision, and management of this increasingly recognized clinical entity.
Keywords: Anti-ro/ssa antibodies, arrhythmia, adults, Autoimmunity, Immunomodulatory therapy
Received: 15 Jan 2025; Accepted: 15 Apr 2025.
Copyright: © 2025 Cao, Lv, Tang and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yanmei Lu, Department of Pacing and Electrophysiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.