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SYSTEMATIC REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1560944
This article is part of the Research Topic Innovative Approaches to Cholangiocarcinoma: Diagnosis, Treatment, and Multidisciplinary Care View all 5 articles
Preoperative glasgow prognostic score was an effective prognostic indicator in patients with biliary tract cancer
Provisionally accepted- Department of Hepatobilliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China
The Glasgow Prognostic Score (GPS) is a well-established prognostic indicator that effectively reflects the inflammatory, nutritional, and immune status of cancer patients. GPS has been shown to be associated with survival outcomes in many different cancers. However, its prognostic significance in biliary tract cancer (BTC) remains unclear. This meta-analysis aims to explore the prognostic value of GPS in BTC patients.Methods: A systematic search was conducted in PubMed, Embase, and Web of Science to identify relevant studies. Survival data including overall survival (OS), disease-free survival (DFS) and recurrence-free survival (RFS) were the main observation indicators. Hazard ratios (HRs) with 95% confidence intervals (CIs) were extracted and pooled for meta-analysis..A total of 16 articles incorporating 1919 patients were included in the study.High GPS was associated with poor OS (HR:2.00, 95% CI:1.62-2.48) and DFS/RFS (HR:2.50, 95% CI:1.71-3.65). Subgroup analysis further confirmed the prognosis value of GPS in BTC patients.Conclusions: GPS could serves as a valuable prognostic marker in BTC patients and may aid in risk stratification and treatment decision-making.
Keywords: Glasgow prognostic score, prognosis, Biliary tract cancer, Meta-analysis, Survival
Received: 15 Jan 2025; Accepted: 14 Mar 2025.
Copyright: © 2025 Liu, Ye, Li, Wangbin, Yu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rongqiang Liu, Department of Hepatobilliary Surgery, Renmin Hospital of Wuhan University, Wuhan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.