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REVIEW article
Front. Immunol.
Sec. T Cell Biology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1560578
The dual role of tissue regulatory T cells in tissue repair: Return to homeostasis or fibrosis
Provisionally accepted- Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shanxi Province, China
Tissue resident regulatory T cells (tissue Tregs) are vital for maintaining immune homeostasis and controlling inflammation. They aid in repairing damaged tissues and influencing the progression of fibrosis. However, despite extensive research on how tissue Tregs interact with immune and non-immune cells during tissue repair, their pro- and anti-fibrotic effects in chronic tissue injury remain unclear. Understanding how tissue Tregs interact with various cell types, as well as their roles in chronic injury and fibrosis, is crucial for uncovering the mechanisms behind these conditions. In this review, we describe the roles of tissue Tregs in repair and fibrosis across different tissues and explore potential strategies for regulating tissue homeostasis. These insights hold promise for providing new perspectives and approaches for the treatment of irreversible fibrotic diseases.
Keywords: tissue regulatory T cells, tissue repair, Fibrosis, immune cells, non-immune cells
Received: 14 Jan 2025; Accepted: 18 Feb 2025.
Copyright: © 2025 Zhang, Wang, Miao and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jinlin Miao, Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shanxi Province, China
Ping Zhu, Department of Clinical Immunology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shanxi Province, China
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