Case report: Guillain-Barré Syndrome with three episodes and literature review

Ying Wang¹Chunmei Zhao²Rong Chen³Zeli Ma¹Nan Tian¹Xuan Li¹XU Xian Rui^2,4Qiang Liu^2,4Yajun Li¹Fenkui She¹Fenglin Mu¹Zhang Qing^2*

• ¹School of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia Hui Region, China
• ²Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Region, China
• ³Department of Neuroelectrophysiology, Cardiovascular and Cerebrovascular Disease Hospital Branch, General Hospital of Ningxia Medical University, Yinchuan, China
• ⁴Ningxia Key Laboratory of Cerebrocranial Disease, Ningxia Medical University, Yinchuan, Ningxia Hui Region, China

Guillain-Barré Syndrome (GBS) is an autoimmune-mediated peripheral neuropathy that is usually monophasic, but recurrence occurs in 2-5% of cases, termed recurrent Guillain-Barré Syndrome (RGBS). We report the case of a 49-year-old male patient who experienced three episodes of bilateral lower extremity numbness and weakness, each progressing to its nadir within four weeks. The first episode was additionally characterized by bilateral upper extremity weakness and dyspnea, while the first two episodes were accompanied by numbness in the fingertips of both hands. Electromyography (EMG) revealed severe axonal damage with concomitant demyelination. Anti-sulfatide IgG antibodies were detected during the third episode. After excluding other demyelinating disorders, a definitive diagnosis of GBS was established, and the symptoms were nearly completely resolved following treatment with intravenous immunoglobulin (IVIG).