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REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1558484
This article is part of the Research TopicImmunity, Atherosclerosis and Cardiovascular Disease: An Interdisciplinary Approach to Cardiometabolic HealthView all 16 articles
Immune in Myocardial Ischemia/Reperfusion Injury: Potential Mechanisms and Therapeutic Strategies
Provisionally accepted- 1Tianjin University of Traditional Chinese Medicine, Tianjin, China
- 2Binzhou Medical University Hospital, Binzhou, Shandong Province, China
- 3The Second Affiliated Hospital of Shandong First Medical University, Tai’an, Shandong Province, China
- 4Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
- 5Tianjin University of Traditional Chinese Medicine Affiliated Baokang Hospital, Nankai, Tianjin, China
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Myocardial infarction (MI), which is characterized by high morbidity and mortality, is a serious threat to human life and health, and timely reperfusion therapy to save ischemic myocardium is currently the most effective intervention. Although reperfusion therapy effectively restores coronary blood flow and maximally limits the infarct size, it triggers additional cell death and tissue damage, which is known as myocardial ischemia/reperfusion injury (MIRI). Multiple immune cells are present in the reperfusion area, executing specific functions and engaging in crosstalk during diverse stages, constituting a complex immune microenvironment involved in tissue repair and regeneration after MIRI. Immunotherapy brings new hope for treating ischemic heart disease by modulating the immune microenvironment. In this paper, we explore the regulatory roles of various immune cells during MIRI and the close relationship between different cell deaths and the immune microenvironment. In addition, we present the current status of research on targeting the immune system to intervene in MIRI, with the expectation of providing a basis for achieving clinical translation.
Keywords: Myocardial ischemia/reperfusion injury1, Myocardial infarction2, Immune cell3, cell death4, immunotherapy5
Received: 10 Jan 2025; Accepted: 14 Apr 2025.
Copyright: © 2025 Xuan, Fan, Zhang, Feng and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Limin Feng, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China
Ming Ren, Tianjin University of Traditional Chinese Medicine Affiliated Baokang Hospital, Nankai, 300193, Tianjin, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.