AUTHOR=Guan Yipan , Cheng Hongjie , Zhang Naiwei , Cai Yanmei , Zhang Qiaoyan , Jiang Xianyang , Wang Ao , Zeng Haixia , Jia Boyi TITLE=The role of the esophageal and intestinal microbiome in gastroesophageal reflux disease: past, present, and future JOURNAL=Frontiers in Immunology VOLUME=16 YEAR=2025 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1558414 DOI=10.3389/fimmu.2025.1558414 ISSN=1664-3224