This article is a correction to:
Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness
Sahithi Attaluri‡
Raghavendra Upadhya†‡
Maheedhar Kodali
Leelavathi N. Madhu
Dinesh Upadhya†
Bing Shuai
Ashok K. Shetty*- Institute for Regenerative Medicine, Department of Molecular and Cellular Medicine, College of Medicine, Texas A&M University Health Science Center, College, Station, TX, United States
A Corrigendum on
Brain-specific increase in leukotriene signaling accompanies chronic neuroinflammation and cognitive impairment in a model of Gulf War Illness
By Attaluri S, Upadhya R, Kodali M, Madhu LN, Upadhya D, Shuai B and Shetty AK (2022) Front. Immunol. 13:853000. doi: 10.3389/fimmu.2022.853000
In the published article, there was an error in Figures 5B–G as published. In Figure 5, the bar charts B, C, D, E, F, G, y-axis labels were inadvertently misspelled as “ng/mg protein”, instead of “pg/mg protein.”. The corrected Figure 5 and its caption appear below.
Figure 5
Figure 5. Animals with chronic Gulf War Illness (GWI) displayed an increased concentration of leukotrienes (LTs) in the brain and brain-derived extracellular vesicles (EVs) in the circulating blood but not in the serum. The bar charts (A–C) compare 5-LOX (A), LTB4 (B), and cysteinyl LT (CysLT; C) concentrations in the hippocampus, (D, E) compare LTB4 (D) and CysLTs (E) concentrations in the cerebral cortex, and (F, G) compare LTB4 and CysLT concentrations in the serum between naïve and GWI rats. The bar charts in (H–K) compare LTB4 and CysLT concentrations in neuron-derived extracellular vesicles (NDEVs H, I) and astrocyte derived EVs (ADEVs; J, K) between naïve and GWI rats. *, p < 0.05; **, p < 0.01; ****, p < 0.0001; NS, not significant.
The authors apologize for this error, and this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: cysteinyl leukotrienes, gulf war illness (GWI), gulf war-related chemicals, cytokines, 5-lipoxygenase, neuroinflammation, leukotriene signaling, blood-brain barrier
Citation: Attaluri S, Upadhya R, Kodali M, Madhu LN, Upadhya D, Shuai B and Shetty AK (2025) Corrigendum: Brain-specific increase in leukotriene signaling accompanies chronic neuroinflammation and cognitive impairment in a model of Gulf War Illness. Front. Immunol. 16:1557065. doi: 10.3389/fimmu.2025.1557065
Received: 08 January 2025; Accepted: 20 January 2025;
Published: 31 January 2025.
Edited and Reviewed by:
Srikant Rangaraju, Emory University, United StatesCopyright © 2025 Attaluri, Upadhya, Kodali, Madhu, Upadhya, Shuai and Shetty. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Ashok K. Shetty, YWtza3JzQHRhbXUuZWR1
†Present addresses: Raghavendra Upadhya, Manipal Center for Biotherapeutics Research, Manipal Academy of Higher Education, Manipal, India
Dinesh Upadhya, Centre for Molecular Neurosciences, Kasturba Medical Hospital, Manipal Academy of Higher Education, Manipal, India
‡These authors have contributed equally to this work and share first authorship