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CASE REPORT article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1556493
This article is part of the Research TopicCancer Immunity and RadiotherapyView all 8 articles
A novel chemotherapy-free regimen combined with photodynamic therapy, target therapy, and immunotherapy in a geriatric male with huge recurrent scalp and facial angiosarcoma: a report of an extremely rare case and literature review
Provisionally accepted
Hao Chen*
Ewetse Paul MaswikitiZedong Feng
Fan Zhang
Lijuan He
Baohong GuXiang LinHuixia LiCaijuan Wang
Yang YuBo XuJize Wang- Lanzhou University Second Hospital, Lanzhou, China
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Angiosarcomas are sporadic vascular neoplasms among the most aggressive subtypes of soft tissue sarcomas. In addition, vast and multiple recurrent superficial scalp and facial angiosarcomas are very complex and extremely difficult to manage. Their occurrence brings about significant social and emotional distress to affected individuals. To date, no specific therapeutic strategy has been the most effective and reliable. Herein, we report a highly unique case of a geriatric male patient with recurrent scalp and facial angiosarcoma successfully treated by a chemotherapy-free regimen consisting of photodynamic therapy (PDT), immunotherapy, and target therapy. Notably, PDT provided promising remarkable auspicious outcomes and proved to be a better therapeutic option for refractory malignant angiosarcomas. Keywords: chemotherapy-free; photodynamic therapy; immunotherapy; target therapy; scalp and facial angiosarcomas; recurrent; geriatric patient
Keywords: Chemotherapy-free, Photodynamic therapy, Immunotherapy, target therapy, scalp and facial angiosarcomas, recurrent, Geriatric patient
Received: 07 Jan 2025; Accepted: 09 Apr 2025.
Copyright: © 2025 Chen, Maswikiti, Feng, Zhang, He, Gu, Lin, Li, Wang, Yu, Xu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hao Chen, Lanzhou University Second Hospital, Lanzhou, China
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