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REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1555518
This article is part of the Research Topic Ferroptosis and regulation mechanism in the tumor immune microenvironment for tumor progression and treatment View all 4 articles
The Role of Non-coding RNA in Ferroptosis of Liver Cancer and Its Impact on Lipid Peroxidation
Provisionally accepted- Mudanjiang Medical University, Mudanjiang, China
Ferroptosis is an iron-dependent programmed death caused by the imbalance of lipid peroxides in cells. Unlike apoptosis, autophagy and necrosis, ferroptosis is mainly induced by the small molecule compound erastin. The main characteristics of ferroptosis were glutathione (GSH) depletion, inactivation of glutathione peroxidase 4 (GPX4) and reactive oxygen species (ROS) promoting lipid peroxidation. Eventually, the imbalance of lipid peroxidation regulation in cells leads to ferroptosis [1] . The lipid metabolic pathway ultimately contributes to ferroptosis through the production of lipid peroxides [2] . In addition, other cellular metabolic pathways can also regulate ferroptosis, such as the antioxidant metabolic pathway, which inhibits ferroptosis by clearing lipid peroxides and reducing cell membrane damage. Long non-coding RNAs (lncRNAs) are non-coding transcripts more than 200 nucleotides in length and are a less classified group of RNA transcripts that are associated with tumorigenesis and metastasis and are more tissue or cell type specific than protein-coding genes. Studies on the molecular profile of lncRNAs in plasma samples from liver cancer patients show that differentially expressed lncRNAs are mainly concentrated in biological functions related to tumorigenesis, such as cell metastasis, immune response and metabolic regulation. With different biological functions in physiological and pathological environments, the specific expression patterns of lncRNAs coordinate cell state, development, differentiation, and disease [3] .
Keywords: long non-coding RNAs, ferroptosis, liver cancer, Lipid Peroxidation, Glutathione
Received: 04 Jan 2025; Accepted: 05 Mar 2025.
Copyright: © 2025 Ding, Huo, Chen, Wang, Xiang, Yidan, Chen and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Peijian Chen, Mudanjiang Medical University, Mudanjiang, China
Lantao Liu, Mudanjiang Medical University, Mudanjiang, China
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