AUTHOR=Li Huanhuan , Ren Chao , Cui Donghai , Wu Tao , Nie Zhiyong TITLE=Case report: Patients with positive HER-2 amplification locally advanced gastroesophageal junction cancer achieved pathologic complete response with the addition of pembrolizumab to chemotherapy plus trastuzumab as neoadjuvant therapy JOURNAL=Frontiers in Immunology VOLUME=16 YEAR=2025 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1555074 DOI=10.3389/fimmu.2025.1555074 ISSN=1664-3224