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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Microbial Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1553757
This article is part of the Research Topic Host-Microbiota Immuno-Interactions for Personalized Microbial Therapeutics View all 4 articles
Pseudomonas aeruginosa enhances anti-PD-1 efficacy in colorectal cancer by activating cytotoxic CD8 + T cells
Provisionally accepted
Lu Chen Guangcong Ruan Xuefei Zhao Ailin Yi Zhifeng Xiao Yuting Tian Yi Cheng Dongfeng Chen *
Yanling Wei *- Department of gastroenterology, Daping Hospital, Army Medical University, Chongqing, China
Immune checkpoint therapy for colorectal cancer (CRC) has been found to be unsatisfactory for clinical treatment. Fecal microbiota transplantation (FMT) has been shown to remodel the intestinal flora, which may improve the therapeutic effect of αPD-1. Further exploration of key genera that can sensitize cells to αPD-1 for CRC treatment and preliminary exploration of immunological mechanisms may provide effective guidance for the clinical treatment of CRC. In this study, 16S rRNA gene sequencing was analyzed in the fecal flora of both responders and no-responders to αPD-1 treatment, and the therapeutic effect was experimentally verified. Pseudomonas aeruginosa was found to be highly abundant in the fecal flora of treated mice, and Pseudomonas aeruginosa mannose-sensitive hemagglutinin (PA-MSHA) in combination with αPD-1 was effective in the treatment of CRC through the induction of CD8 + T-cell immunological effects. The clinical drug PA-MSHA can be used in combination with αPD-1 for the treatment of CRC as a potential clinical therapeutic option.
Keywords: αPD-1, Pseudomonas aeruginosa, PA-MSHA, CRC, CD8+T cell
Received: 31 Dec 2024; Accepted: 04 Mar 2025.
Copyright: © 2025 Chen, Ruan, Zhao, Yi, Xiao, Tian, Cheng, Chen and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dongfeng Chen, Department of gastroenterology, Daping Hospital, Army Medical University, Chongqing, China
Yanling Wei, Department of gastroenterology, Daping Hospital, Army Medical University, Chongqing, China
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