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REVIEW article
Front. Immunol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1552704
This article is part of the Research Topic New Strategies for Spinal Cord Injury and Immunotherapy Targeting Novel Programmed Death Pathways View all 3 articles
Roles of METTL3 and NLRP3 in pyroptosis and prospects in SCIRI
Provisionally accepted- 1 Departments of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Hebei Province, China
- 2 Departments of Orthopedics, Jilin Province People's Hospital, Changchun, China
Spinal cord ischemia-reperfusion injury (SCIRI) leads to severe neurological deficits, with pyroptosis emerging as a key driver of inflammation and neuronal death. Recent studies suggest that methyltransferase-like 3 (METTL3), a critical RNA methyltransferase, may regulate the nucleotidebinding oligomerized structural domain-like receptor protein 3 (NLRP3) inflammasome activation via N6-Methyladenosine (m6A) modification, yet direct evidence in SCIRI remains limited. This review synthesizes current knowledge on the METTL3-NLRP3 axis in pyroptosis, explores its therapeutic potential, and identifies critical research gaps for future investigation.
Keywords: SCIRI, pyroptosis, NLRP3, METTL3, sci
Received: 02 Jan 2025; Accepted: 19 Mar 2025.
Copyright: © 2025 Guan, Zhang, Zhang, Li and Yin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guangchun Li, Departments of Orthopedics, Jilin Province People's Hospital, Changchun, China
Fei Yin, Departments of Orthopedics, China-Japan Union Hospital of Jilin University, Changchun, Hebei Province, China
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