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REVIEW article
Front. Immunol.
Sec. Mucosal Immunity
Volume 16 - 2025 |
doi: 10.3389/fimmu.2025.1552010
This article is part of the Research Topic Natural Constituents and Mucosal Immunity: Immune Protection and Treatment of Mucosal Barriers and Microbial Flora Using Omics Technologies and Gene Sequencing View all 4 articles
Influence of gut microbial metabolites on tumor immunotherapy: mechanisms and potential natural products
Provisionally accepted
Dongyang Li 1*
Xintian Lan 1*
Linyi Xu 1 Shuo Zhou 1*
Haoming Luo 1 Xiaoying Zhang 2* Wenbo Yu 1* Yonggang Yang 1*
Xiaoxue Fang 1*- 1 Changchun University of Chinese Medicine, Changchun, China
- 2 First Affiliated Hospital of Jilin University, Changchun, Jilin Province, China
In recent years, tumor immunotherapy has made significant breakthroughs in the treatment of malignant tumors. However, individual differences in efficacy have been observed in clinical practice. There is increasing evidence that gut microbial metabolites influence the efficacy of distal tumor immunotherapy via the gut-liver axis, the gut-brain axis and the gut-breast axis, a process that may involve modulating the expression of immune cells and cytokines in the tumor microenvironment (TME). In this review, we systematically explore the relationship between gut microbial metabolites and tumor immunotherapy, and examine the corresponding natural products and their mechanisms of action. The in-depth exploration of this research area will provide new ideas and strategies to enhance the efficacy of tumor immunotherapy and mitigate adverse effects.
Keywords: Gut microbial metabolites1, Tumor2, natural products3, Immune4, mechanism5
Received: 27 Dec 2024; Accepted: 06 Feb 2025.
Copyright: © 2025 Li, Lan, Xu, Zhou, Luo, Zhang, Yu, Yang and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dongyang Li, Changchun University of Chinese Medicine, Changchun, China
Xintian Lan, Changchun University of Chinese Medicine, Changchun, China
Shuo Zhou, Changchun University of Chinese Medicine, Changchun, China
Xiaoying Zhang, First Affiliated Hospital of Jilin University, Changchun, 130012, Jilin Province, China
Wenbo Yu, Changchun University of Chinese Medicine, Changchun, China
Yonggang Yang, Changchun University of Chinese Medicine, Changchun, China
Xiaoxue Fang, Changchun University of Chinese Medicine, Changchun, China
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