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CASE REPORT article
Front. Immunol.
Sec. T Cell Biology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1552000
This article is part of the Research TopicLymphocytes and Autoimmune Disease: from molecular mechanism to clinical implicationsView all 7 articles
The absolute number of T lymphocyte subtsets is beneficial for differential diagnosis of Myelodysplastic syndrome with Pure red cell aplastic anemia: A case report and review of the literature
Provisionally accepted
Liangjun Zhang*
huixiu zhong- Zigong First People's Hospital, Zigong, China
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The two diseases of Myelodysplastic syndrome (MDS) and Pure red cell aplasia (PRCA) are independent of each other and can be linked in some cases. the diagnosis and differential diagnosis are very confusing. So in order to understand the relationship between MDS and PRCA, and improve the diagnosis and treatment of MDS in patient with PRCA. We present a case study of a 71-year-old male patient with anemia. the result of morphological examination of bone marrow, whole-genome microarray and bone marrow biopsy all supported diagnose of MDS at the first clinical diagnosis. Azacitidine and Venetoclax chemotherapy were given to the patient. But the treatment is not effective, and the absolute number of T lymphocyte subsets decreased gradually during treatment. Then, treatment plan was changed to Cyclosporine A plus Prednisone for immune regulation. the absolute number of T lymphocyte subsets and Hemoglobin (Hb) rose rapidly, and final diagnose of the patient was MDS with PRCA. To improve the ability to diagnose MDS with PRCA, we should combine with the absolute number of T lymphocytes to monitor efficacy evaluation during treatment, it contribute to the differential diagnosis of MDS with PRCA.
Keywords: T lymphocyte subtsets, myelodysplastic syndrome, pure red cell aplasia, differential diagnosis, Treatment
Received: 27 Dec 2024; Accepted: 09 Apr 2025.
Copyright: © 2025 Zhang and zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liangjun Zhang, Zigong First People's Hospital, Zigong, China
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