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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1550988
Knowledge mapping of tumor microenvironment for breast cancer: A bibliometric analysis from 2014 to 2023
Provisionally accepted
Dongping Jiang 1,2
ping Wen 1,2
Senmiao Zhang 1,2
Ningning Zhang 2
Qing Shao 2 Guanwen Wang 2
Long Wang 2 Sisi Li 2 Yang Qin 2
Fanli Qu 2*
Xiaohua Zeng 1,2*- 1 Chongqing University, Chongqing, China
- 2 Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Cancer Hospital, Chongqing University, Chongqing, China
Breast cancer is the most common malignant tumor among women worldwide, and the tumor microenvironment (TME) has become a hot research field in contemporary oncology. Understanding the TME is essential for elucidating the mechanisms of breast cancer progression and identifying novel therapeutic targets for metastasis and recurrence. This study performed a bibliometric analysis of TME research for breast cancer, providing a comprehensive overview of current research hotspots, development trends, and directions. We retrieved for literature on TME for breast cancer published during 2014-2023 from the Web of Science database and performed bibliometric analysis. CiteSpace was used for co-citation analysis of references to assess the evolution and bursts in the knowledge base. VOSviewer was used for co-occurrence analysis of author keywords, countries/regions, institutions, and authors to reveal the knowledge structure and collaborative networks in this research area. Thematic evolution trends were analyzed using the bibliometrix package to reveal research hotspots, thematic evolution and dynamic changes of this research. A total of 9683 documents were included in this study, and the keyword co-occurrence analysis displayed five clusters: immunotherapy, metastasis, diagnosis and prognosis, metabolic regulation, and therapeutic approaches, with the first two keywords, immunotherapy and metastasis, being the most frequently mentioned. The most productive country/region, institution, and author were China (3266 publications), Shanghai Jiao Tong University (208 publications), and Takahashi, Kazuaki (37 publications).In breast cancer TME research, cancer-associated fibroblasts have attracted widespread attention, while cancer immunotherapy has emerged as a key focus in contemporary studies.
Keywords: breast cancer, Tumor Microenvironment, Bibliometric, Immunotherapy, metastasis
Received: 24 Dec 2024; Accepted: 11 Mar 2025.
Copyright: © 2025 Jiang, Wen, Zhang, Zhang, Shao, Wang, Wang, Li, Qin, Qu and Zeng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fanli Qu, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Cancer Hospital, Chongqing University, Chongqing, 400030, China
Xiaohua Zeng, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Cancer Hospital, Chongqing University, Chongqing, 400030, China
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