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REVIEW article
Front. Immunol.
Sec. Inflammation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1550226
NLRP3 Inflammasome in cardiovascular diseases: an update
Provisionally accepted- 1 People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China
- 2 First People's Hospital of Nanning, Nanning, Guangxi Zhuang Region, China
Cardiovascular disease (CVD) continues to be the leading cause of mortality worldwide. The nucleotide oligomerization domain-, leucine-rich repeat-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is involved in numerous types of CVD. As part of innate immunity, the NLRP3 inflammasome plays a vital role, requiring priming and activation signals to trigger inflammation. The NLRP3 inflammasome leads both to the release of IL-1 family cytokines and to a distinct form of programmed cell death called pyroptosis. Inflammation related to CVD has been extensively investigated in relation to the NLRP3 inflammasome. In this review, we describe the pathways triggering NLRP3 priming and activation and discuss its pathogenic effects on CVD. This study also provides an overview of potential therapeutic approaches targeting the NLRP3 inflammasome.
Keywords: NLRP3, cardiovacsular diseases, Inflammation, pyroptosis, Inflammasome
Received: 23 Dec 2024; Accepted: 11 Feb 2025.
Copyright: © 2025 Mo, Di and Ji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qingwei Ji, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China
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