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REVIEW article
Front. Immunol.
Sec. Alloimmunity and Transplantation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1548735
This article is part of the Research Topic Multi-omics Assessment for the Discovery of Promising Novel Molecules in the Treatment of Transplant Organ Injury View all articles
Current Understanding on Inferior Quality of Liver Grafts by Donation after Circulatory Death based on Multi-omics Data
Provisionally accepted- Zhejiang Shuren University, Hangzhou, China
Given the inevitable hypoxia and reperfusion injury that occur in organs donated after circulatory death (DCD), the quality and function of these organs are significantly compromised, greatly limiting their application in clinical organ transplantation. Recently, the advancement of functional omics technologies has enabled us to deeply analyze the mechanisms underlying DCD donor organ damage from multiple perspectives. This review systematically integrates the studies from transcriptomics, proteomics, and metabolomics to reveal the key biological mechanisms associated with the declines in DCD donor organ quality, including oxidative stress, inflammatory responses, cell death pathways, and metabolic disturbances. Additionally, we summarized emerging therapeutic strategies based on findings from omics perspectives, offering new possibilities to improve the quality of DCD organ for better transplant prognosis. Finally, we discussed the challenges in current research and future directions to provide scientific evidence for clinical practice and promote the application of DCD donors in organ transplantation.
Keywords: Donation after circulatory death, Liver Transplantation, multi-omics, ischemia-reperfusion injury, Oxidative Stress, Inflammatory Response
Received: 20 Dec 2024; Accepted: 03 Mar 2025.
Copyright: © 2025 Zhou, Lu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhengtao Liu, Zhejiang Shuren University, Hangzhou, China
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