Skip to main content

ORIGINAL RESEARCH article

Front. Immunol.
Sec. Nutritional Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1546612
This article is part of the Research Topic Nutritional Challenges and Therapies in Youth with Chronic Inflammatory Diseases View all articles

Association between systemic immune-inflammation index and central obesity in pediatric populations: a crosssectional and cohort study

Provisionally accepted
Qian Zhang Qian Zhang 1Bingxuan Kong Bingxuan Kong 1Zhiyu Zhou Zhiyu Zhou 1Fangqu Liu Fangqu Liu 1Erya Wen Erya Wen 2Bingliang Lin Bingliang Lin 2Xuan Peng Xuan Peng 2Wenlong Lu Wenlong Lu 2Zhe Su Zhe Su 3Yanyan Li Yanyan Li 2Yuhan Tang Yuhan Tang 1Jingfan Xiong Jingfan Xiong 2Ping Yao Ping Yao 1*Yan Li Yan Li 2*
  • 1 Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
  • 2 Shenzhen Chronic Disease Prevention Center, Shenzhen, China
  • 3 Shenzhen Children's Hospital, Shenzhen, Guangdong Province, China

The final, formatted version of the article will be published soon.

    Background: Central obesity in children represents a significant public health concern due to its strong association with an elevated risk of metabolic and cardiovascular disorders. The systemic immune inflammation index (SII) has been implicated in the pathophysiology of obesity-related chronic inflammation. Despite its potential relevance, the specific relationship between central obesity and SII in the pediatric population remains insufficiently explored. The objective of this study was to examine the relationship between SII and central obesity, with a particular focus on the potential of SII as a predictor of central obesity and a means of preventing obesity at an early stage of life. linear models. The restricted cubic spline regression was used to explore the nonlinear relationship between SII and obesity indicators. In a prospective study, we employed a modified Poisson regression model to investigate the potential causal relationship between SII and central obesity.Results: Cross-sectionally, adolescents in the highest quartile of SII levels exhibited the greatest risk for central obesity(OR=3.07, 95% CI:2.45~3.87) when compared to those in the lowest quartile. Subgroup analyses showed that higher SII was associated with central obesity. Longitudinally, individuals in the highest SII quartile were found to have the highest risk of developing central obesity (RR=1.83, 95% CI:1.18~2.83) over time.

    Keywords: immune-inflammation index(SII), Central obesity, Children and adolescents, cohort study, Inflammation

    Received: 17 Dec 2024; Accepted: 03 Feb 2025.

    Copyright: © 2025 Zhang, Kong, Zhou, Liu, Wen, Lin, Peng, Lu, Su, Li, Tang, Xiong, Yao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Ping Yao, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei Province, China
    Yan Li, Shenzhen Chronic Disease Prevention Center, Shenzhen, 518020, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.