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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Nutritional Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1546031
This article is part of the Research Topic Community Series in Gut Microbiota and Immunity in Health and Disease: Dysbiosis and Eubiosis's Effects on the Human Body, Volume II View all 3 articles
Microbiota-Friendly Diet Ameliorates Hypoalbuminemia in Chronic Kidney Disease: Evidence from NHANES
Provisionally accepted- 1 Department of Clinical Nutrition, First Affiliated Hospital of Chengdu Medical College, Chengdu, China
- 2 Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Chengdu, China
- 3 Department of Nephrology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China
- 4 Department of Vascular Surgery, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Chengdu, China
- 5 Department of Neurosurgery, Chengdu Seventh People’s Hospital, Sichuan Province, ChengDu, China
Chronic kidney disease (CKD) is a global health issue, affecting approximately 10% of the population. Hypoalbuminemia, a common complication in advanced CKD, is associated with poor prognosis. This study aimed to investigate the association between a microbiota-friendly dietary scoring system (Dietary Index for Gut Microbiota, DI-GM) and serum albumin levels in patients with CKD. We utilized a cross-sectional cohort from the NHANES 2007-2018, which included 2,947 CKD patients. Multivariable logistic regression and restricted cubic spline models were applied to analyze the relationship between DI-GM scores and serum albumin. Higher DI-GM scores were significantly associated with increased serum albumin levels (β = 0.18 g/L, 95% CI: 0.07-0.28, p = 0.002). Furthermore, each 1-point increase in DI-GM score was linked to a 15% reduction in the odds of hypoalbuminemia (OR: 0.85, 95% CI: 0.74-0.97, p = 0.014).The findings suggest that a high DI-GM diet may have beneficial effects in managing hypoalbuminemia in CKD patients by modulating gut microbiota composition and reducing inflammation. This diet pattern could be a promising dietary intervention for improving clinical outcomes in CKD patients, especially those at risk for malnutrition and inflammation.
Keywords: CKD, Dietary Index for Gut Microbiota, Serum Albumin, Hypoalbuminemia, dietary pattern
Received: 16 Dec 2024; Accepted: 07 Apr 2025.
Copyright: © 2025 Wang, Wen, Gao, Zhao and Miao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Shuchuan Miao, Department of Neurosurgery, Chengdu Seventh People’s Hospital, Sichuan Province, ChengDu, China
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