95% of researchers rate our articles as excellent or good
Learn more about the work of our research integrity team to safeguard the quality of each article we publish.
Find out more
REVIEW article
Front. Immunol.
Sec. Alloimmunity and Transplantation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1544960
This article is part of the Research Topic Innovative Approaches to Immunogenetics and Organ Transplantation View all articles
Triple role of Exosomes in lung transplantation
Provisionally accepted- 1 Department of Thoracic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
- 2 Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China
- 3 Department of Cardiac Surgery, Sun Yat-Sen Memorial Hospital, Guangzhou, China
Exosomes are tiny vesicles secreted by the vast majority of cells and play an important role in physiological as well as pathological processes in the body.Circulating exosomes in Lung Transplant Recipients (LTxR) undergoing rejection contain mismatched Human Leukocyte Antigens (HLA) and lung-associated autoantigens (e.g., K-alpha1 microtubule protein and collagen V), which may induce autoantibodies, and the circulating exosomes trigger an immune response that results in rejection of the lung transplant recipient. This article discusses the role of exosomes in lung transplantation from three perspectives: exosomes as a biomarker for rejection after lung transplantation; the mechanism of exosome-mediated activation of the immune response; and the potential of exosomes as a therapeutic strategy.
Keywords: exosome, Lung Transplantation, DCs, Biomark assay, Allograft immunization
Received: 13 Dec 2024; Accepted: 21 Mar 2025.
Copyright: © 2025 Rao, Huang, Xie, Zhu, Tang, Wu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Dingyu Rao, Department of Thoracic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
Zuxiong Zhang, Department of Thoracic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.