AUTHOR=Brieva Luis , Calles Carmen , Landete Lamberto , Oreja-Guevara Celia TITLE=Current challenges in secondary progressive multiple sclerosis: diagnosis, activity detection and treatment JOURNAL=Frontiers in Immunology VOLUME=Volume 16 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1543649 DOI=10.3389/fimmu.2025.1543649 ISSN=1664-3224