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REVIEW article
Front. Immunol.
Sec. Immunological Tolerance and Regulation
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1542438
This article is part of the Research Topic Metabolite-induced Metabolic Reprogramming in the Immune System View all articles
Dynamic Regulation of Neutrophil Immunometabolism by Platelet-Derived Metabolites
Provisionally accepted- 1 National Polytechnic Institute (IPN), Mexico City, Mexico
- 2 Departamento de MicrobiologÃa, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Mexico, Mexico
- 3 Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States
- 4 Laboratorio Nacional de VacunologÃa y Virus Tropicales (LNVyVT), Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional, Ciudad de Mexico, Mexico
Platelets, traditionally known for their roles in hemostasis and thrombosis, have emerged as key regulators of immune responses, particularly through their dynamic interactions with neutrophils. This review explores how platelets -derived metabolites influence neutrophil functions by forming platelet-neutrophil aggregates, releasing extracellular vesicles, and secreting metabolitessoluble mediators. These processes govern critical immune activities, including cell recruitment, activation, endothelium interactions and the inflammation resolution or exacerbation of inflammation. Additionally, platelets induce metabolic reprogramming in neutrophils, affecting glycolysis and mitochondrial pathways, while also shaping the immune microenvironment by modulating other immune cells, such as T and B cells. Understanding this complex crosstalk between platelets and neutrophils-two of the most abundant cell types in the bloodstream-might reveals new therapeutic opportunities to regulate immune responses in inflammatory and immune-mediated diseases.
Keywords: Neutrophil immunometabolism, Platelet-derived metabolites, mitochondrial metabolism, Platelet-neutrophil aggregates, Inflammation regulation
Received: 09 Dec 2024; Accepted: 03 Mar 2025.
Copyright: © 2025 Mosso-Pani, Barreda and Salazar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ma Isabel Salazar, National Polytechnic Institute (IPN), Mexico City, Mexico
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