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REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1541950
This article is part of the Research Topic TLS Heterogeneity in the Tumor Microenvironment and Immunotherapy: Mechanistic Studies and Target Exploration View all articles
Tissue-Resident Immune Cells in Cervical Cancer: Emerging Roles and Therapeutic Implications
Provisionally accepted- Zhuzhou Central Hospital, Zhuzhou, China
The favorable prognosis of "hot" tumors is widely acknowledged in oncology. Recently, the concept of tertiary lymphoid structures (TLS) has renewed appreciation for local immune cells within tumor tissues. Tissue-resident immune cells, a newly identified subset of tumor-infiltrating lymphocytes, are emerging as potential key players in tumor infiltration and TLS formation, due to their ability to reside indefinitely within tissues and mount effective responses to local antigens. Cervical cancer (CC), the fourth most common cause of cancer-related mortality among women globally, has experienced comparatively limited progress in delineating its tumor immune microenvironment compared to other malignancies. Notably, the role of tissue-resident immune cells within the CC milieu remains inadequately characterized. This comprehensive review aims to synthesize current knowledge and critically evaluate the putative roles of these cells in CC pathogenesis, providing new insights on the intricate dynamics of the local tumor microenvironment.
Keywords: cervical cancer, tissue-resident immune cells, Local tumor microenvironment, Trm Cell Differentiation, tissue-resident memory T cells
Received: 09 Dec 2024; Accepted: 02 Apr 2025.
Copyright: © 2025 Li, Deng, Liu, Zhou, Bi, Chen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jinjin Wang, Zhuzhou Central Hospital, Zhuzhou, China
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