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ORIGINAL RESEARCH article
Front. Immunol.
Sec. Comparative Immunology
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1539751
This article is part of the Research TopicCell-mediated innate immunity in aquatic invertebrates and fish: what’s new?View all 6 articles
Bioinformatics analyses of proteome of Holothuria tubulosa coelomic fluid and first evidence of primary cilium in coelomocyte cells
Provisionally accepted
Laura La Paglia1
Manuela Mauro2
Vincenzo Arizza2
Alfonso Urso1Simon Sugár3Drahos Laszlo3
Vita Di Stefano2Claudio Luparello2
Mirella Vazzana2
Aiti Vizzini2*- 1National Research Council (CNR), Roma, Lazio, Italy
- 2University of Palermo, Palermo, Italy
- 3Research Centre for Natural Sciences, Hungarian Academy of Sciences (MTA), Budapest, Hungary
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In this work, we use the close phylogenetic relationship between H. tubulosa and vertebrates to study the evolution of immune genes. We propose a novel schematic model representing the putative interplay of immune-related proteins between extracellular and intracellular H. tubulosa in coelomic fluid (Fig. 8). In particular, in intracellular protein fraction, we identified an ancestral structure r ecalling vertebrate primary cilium, together with putative actin and cytoskeleton remodeling activated after pathogen sensing. This aims to cover knowledge gaps regarding mechanisms modulating specific immune cell phenotypes, behaviours, and functions highly conserved throughout evolution, involved in immune interactions with pathogens.
Keywords: Conceptualization, Data curation, Formal analysis, Funding acquisition, investigation, supervision, Writing -original draft, Writing -review & editing. Alfonso Urso: Funding acquisition
Received: 04 Dec 2024; Accepted: 07 Apr 2025.
Copyright: © 2025 La Paglia, Mauro, Arizza, Urso, Sugár, Laszlo, Di Stefano, Luparello, Vazzana and Vizzini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Aiti Vizzini, University of Palermo, Palermo, Italy
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