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REVIEW article

Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1539396
This article is part of the Research Topic Exploring the Intersection of Cancer Metabolism, Metastasis and Immunotherapy View all articles

Manipulating the cGAS-STING Axis: Advancing Innovative Strategies for Osteosarcoma Therapeutics

Provisionally accepted
Bingbing Li Bingbing Li 1Cheng Zhang Cheng Zhang 1Xiaojuan Xu Xiaojuan Xu 1Qiqin Shen Qiqin Shen 1Shunan Luo Shunan Luo 2Junfeng Hu Junfeng Hu 2*
  • 1 Shaoxing Central Hospital, Shaoxing, China
  • 2 Shaoxing People's Hospital, Shaoxing, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    This paper explored the novel approach of targeting the cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator of interferon genes (cGAS-STING) pathway for the treatment of osteosarcoma (OS).Osteosarcoma is a common malignancy in adolescents. Most patients die from lung metastasis. It reviewed the epidemiology and pathological characteristics of OS, highlighting its highly malignant nature and tendency for pulmonary metastasis, underscoring the importance of identifying new therapeutic targets. The cGAS-STING pathway was closely associated with the malignant biological behaviors of OS cells, suggesting that targeting this pathway could be a promising therapeutic strategy. Currently, research on the role of the cGAS-STING pathway in OS treatment has been limited, and the underlying mechanisms remain unclear.Therefore, further investigation into the mechanisms of the cGAS-STING pathway in OS and the exploration of therapeutic strategies based on this pathway are of great significance for developing more effective treatments for OS. This paper offered a fresh perspective on the treatment of OS, providing hope for new therapeutic options for OS patients by targeting the cGAS-STING pathway.

    Keywords: Osteosarcoma, cGAS-STING, treatment target, drug, tumor immunity

    Received: 04 Dec 2024; Accepted: 15 Jan 2025.

    Copyright: © 2025 Li, Zhang, Xu, Shen, Luo and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Junfeng Hu, Shaoxing People's Hospital, Shaoxing, 312000, Zhejiang Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.