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MINI REVIEW article
Front. Immunol.
Sec. Molecular Innate Immunity
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1538282
The Dual Role of Neutrophils in Sepsis-associated Liver Injury Article type: Mini Review
Provisionally accepted- Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China
Sepsis is often accompanied by liver injury and is associated with an increase in the number of circulating and hepatic neutrophils. In sepsis-associated liver injury, neutrophils exhibit phenotypic heterogeneity and perform both pro-and anti-inflammatory functions. Moreover, neutrophil dysfunction and neutrophil-associated immunosuppression are also involved in the pathogenesis of sepsis. Given the complex functionality of this cell type, the aim of this review was to describe the possible mechanistic role of neutrophils in sepsis-associated liver injury, with a brief introduction to neutrophil recruitment and subsequent discussion of the potential contributions of neutrophils to different subtypes of sepsis-associated liver injury.
Keywords: Immunosuppression, Inflammation, liver injury, Neutrophil, Sepsis
Received: 02 Dec 2024; Accepted: 17 Feb 2025.
Copyright: © 2025 Fang, Song, Chen and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yueping Ding, Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China
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