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MINI REVIEW article
Front. Immunol.
Sec. Cancer Immunity and Immunotherapy
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1537615
This article is part of the Research Topic Post-Transcriptional Modifications in Cancer Immunity and Immunotherapy View all 3 articles
PARylation-Mediated Post-Transcriptional Modifications in Cancer Immunity and Immunotherapy
Provisionally accepted- Okayama University, Okayama, Japan
Poly-ADP-ribosylation (PARylation) is a post-translational modification in which ADPribose is added to substrate proteins. PARylation is mediated by a superfamily of ADPribosyl transferases known as PARPs and influences a wide range of cellular functions, including genome integrity maintenance, and the regulation of proliferation and differentiation. We and others have recently reported that PARylation of SH3 domainbinding protein 2 (3BP2) plays a role in bone metabolism, immune system regulation, and cytokine production. Additionally, PARylation has recently gained attention as a target for cancer treatment. In this review, we provide an overview of PARylation, its involvement in several signaling pathways related to cancer immunity, and the potential of combination therapies with PARP inhibitors and immune checkpoint inhibitors.
Keywords: PARylation, Cancer, post-transcriptional regulation, ubiquitylation, Immune System
Received: 01 Dec 2024; Accepted: 17 Feb 2025.
Copyright: © 2025 Matsumoto, Matsumoto and Wada. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yoshinori Matsumoto, Okayama University, Okayama, Japan
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