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ORIGINAL RESEARCH article

Front. Immunol.
Sec. Vaccines and Molecular Therapeutics
Volume 16 - 2025 | doi: 10.3389/fimmu.2025.1535758

A Modified mRNA Vaccine prevents Enterovirus A71 Infection in mouse model

Provisionally accepted
Yuming Li Yuming Li 1*Fengyu Chi Fengyu Chi 1Xu Zhang Xu Zhang 1Dong Zhang Dong Zhang 1Airu Zhu Airu Zhu 2Zhen Zhuang Zhen Zhuang 2Zhaoyong Zhang Zhaoyong Zhang 2Zhenjie Zhang Zhenjie Zhang 1Chuansong Quan Chuansong Quan 1Kaixiao Nie Kaixiao Nie 1Juan Li Juan Li 1Chunhong Yin Chunhong Yin 3Jie Tong Jie Tong 4
  • 1 Shandong First Medical University & Shandong Academy of Medical Sciences, ji'nan, China
  • 2 First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong Province, China
  • 3 Shandong Center for Disease Control and Prevention, Shandong, China
  • 4 Hebei University, Baoding, Hebei Province, China

The final, formatted version of the article will be published soon.

    Human Enterovirus A71 (EV-A71) is the primary pathogen responsible for severe cases of hand, foot, and mouth disease (HFMD). Vaccination plays a crucial role in controlling its spread. Despite inactivated vaccines have been approved, new candidates based on advanced technological platforms are actively being developed.The mRNA vaccine platform, an innovative approach to vaccine development, has been predominantly used for enveloped viruses, with relatively limited application for non-enveloped viruses. In this study, we applied the mRNA vaccine strategy to target the VP1 protein of the non-enveloped EV-A71 virus, creating a novel vaccine capable of inducing robust humoral and strong T-cell immune responses in mice, which effectively protected them against lethal doses of EV-A71. Overall, our EV-A71 mRNA vaccine shows great promise as a candidate for preventing EV-A71 infection.

    Keywords: human enterovirus A71, non-enveloped virus, VP1, mRNA vaccine, immune response

    Received: 27 Nov 2024; Accepted: 24 Jan 2025.

    Copyright: © 2025 Li, Chi, Zhang, Zhang, Zhu, Zhuang, Zhang, Zhang, Quan, Nie, Li, Yin and Tong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yuming Li, Shandong First Medical University & Shandong Academy of Medical Sciences, ji'nan, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.